Document Type

Article

Publication Date

3-30-2026

Comments

This article is the author’s final published version in Journal of Shoulder and Elbow Arthroplasty, Volume 10, Issue 1-2, 2026, Article number 100010.

The published version is available at https://doi.org/10.1016/j.jsea.2026.100010. Copyright © 2026 The Author(s).

Abstract

Background Antiplatelet therapy is widely prescribed for the prevention and management of cardiovascular disease and for mitigation of thromboembolic risk. However, its impact on post-operative periprosthetic joint infection (PJI) following total shoulder arthroplasty (TSA) remains poorly defined.MethodsA retrospective cohort study was conducted using the TriNetX US Research Network. Propensity score matching was performed to balance demographics, body mass index, and Charlson Comorbidity Index variables. The primary outcome was the incidence of PJI at 90 days, 6 months, and 1 year. Secondary outcomes included post-operative medical and surgical complications. Comparative risk was quantified using risk ratios with 95% confidence intervals. Subgroup analyses evaluated obese, frail, as well as antiplatelet subclass groups.ResultsFollowing 1:1 propensity score matching, 51,020 patients remained in each cohort. Pre-operative antiplatelet use was associated with a significantly higher risk of PJI at 90 days (risk ratio [RR], 2.00), 6 months (RR, 1.87), and 1 year (RR, 1.80) (all P < .001). Secondary outcomes demonstrated higher rates of healthcare utilization, myocardial infarction, surgical site infection, and revision across all time points, while venous thromboembolism rates were largely comparable between groups. Subgroup analyses in obese and frail patients demonstrated persistently elevated risks associated with antiplatelet therapy. Dual antiplatelet therapy was associated with the highest complication rates, whereas low-dose aspirin demonstrated a more favorable safety profile compared with clopidogrel and high-dose aspirin.ConclusionPre-operative antiplatelet therapy in patients undergoing TSA was associated with an increased risk of PJI and higher rates of post-operative medical and surgical complications. These findings suggest that antiplatelet exposure may represent an important modifiable risk factor for infection following TSA and should be carefully considered during perioperative risk stratification and surgical optimization.

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This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English

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