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This article is the author's final published version in Antibiotics, Volume 12, Issue 6, 2023, Article number 1054.

The published version is available at Copyright © 2023 by the authors. Licensee MDPI, Basel, Switzerland.


Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities for the identification of infections in this setting.

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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.