We describe the inpatient clinical rehabilitation course of three patients with neuromyelitis optica (NMO; Devic’s Syndrome). These patients had varying functional deficits. Each patient improved in several functional independence measures (FIM domains), but had minimal to no progress in other domains after acute rehabilitation stays between 1 to 1.5 months. NMO is a severe central nervous system demyelinating syndrome distinct from MS, characterized by optic neuritis, myelitis, and at least two of three criteria: longitudinally extensive cord lesion, MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity. Persons with NMO may demonstrate improved function with rehabilitation efforts; though gains may be lost to relapse Future immunomodulatory intervention may augment the benefits of rehabilitation.
Schreiber, Adam L.; Fried, Guy W.; Formal, Christopher S.; and DeSouza, Bryan X., "Rehabilitation of Neuromyelitis Optica (Devic’s Syndrome): 3 Case Reports" (2008). Department of Rehabilitation Medicine Faculty Papers. Paper 3.