Larynx-sparing techniques using intensity-modulated radiation therapy for oropharyngeal cancer.

Authors

Voichita Bar-Ad, Thomas Jefferson UniversityFollow
Haibo Lin, University of PennsylvaniaFollow
Wei-Ting Hwang, University of PennsylvaniaFollow
Curtiland Deville, University of PennsylvaniaFollow
Pinaki R Dutta, University of Pennsylvania
Zelig Tochner, University of PennsylvaniaFollow
Stefan Both, University of PennsylvaniaFollow

Document Type

Article

Publication Date

1-1-2012

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Medical Dosimetry

Volume 37, Issue 4, 2012, Pages 383-386

The published version is available at DOI: 10.1016/j.meddos.2012.02.004. Copyright © Elsevier Inc.

Abstract

The purpose of the current study was to explore whether the laryngeal dose can be reduced by using 2 intensity-modulated radiation therapy (IMRT) techniques: whole-neck field IMRT technique (WF-IMRT) vs. junctioned IMRT (J-IMRT). The effect on planning target volumes (PTVs) coverage and laryngeal sparing was evaluated. WF-IMRT technique consisted of a single IMRT plan, including the primary tumor and the superior and inferior neck to the level of the clavicular heads. The larynx was defined as an organ at risk extending superiorly to cover the arytenoid cartilages and inferiorly to include the cricoid cartilage. The J-IMRT technique consisted of an IMRT plan for the primary tumor and the superior neck, matched to conventional antero-posterior opposing lower neck fields at the level of the thyroid notch. A central block was used for the anterior lower neck field at the level of the larynx to restrict the dose to the larynx. Ten oropharyngeal cancer cases were analyzed. Both the primary site and bilateral regional lymphatics were included in the radiotherapy targets. The averaged V95 for the PTV57.6 was 99.2% for the WF-IMRT technique compared with 97.4% (p = 0.02) for J-IMRT. The averaged V95 for the PTV64 was 99.9% for the WF-IMRT technique compared with 98.9% (p = 0.02) for J-IMRT and the averaged V95 for the PT70 was 100.0% for WF-IMRT technique compared with 99.5% (p = 0.04) for J-IMRT. The averaged mean laryngeal dose was 18 Gy with both techniques. The averaged mean doses within the matchline volumes were 69.3 Gy for WF-MRT and 66.2 Gy for J-IMRT (p = 0.03). The WF-IMRT technique appears to offer an optimal coverage of the target volumes and a mean dose to the larynx similar with J-IMRT and should be further evaluated in clinical trials.

Recommended Citation

Bar-Ad, Voichita; Lin, Haibo; Hwang, Wei-Ting; Deville, Curtiland; Dutta, Pinaki R; Tochner, Zelig; and Both, Stefan, "Larynx-sparing techniques using intensity-modulated radiation therapy for oropharyngeal cancer." (2012). Department of Radiation Oncology Faculty Papers. Paper 25.
https://jdc.jefferson.edu/radoncfp/25

PubMed ID

22917963