Document Type
Article
Publication Date
3-20-2023
Abstract
BACKGROUND: Hemangioblastoma of the central nervous system is an uncommon benign neoplasm, with about 25% of cases in patients with von Hippel-Lindau disease. The incidence of metastasis is rare, particularly in patients without von Hippel-Lindau disease. We report a case of hemangioblastoma with leptomeningeal dissemination as a late recurrence.
CASE PRESENTATION: A 65-year-old Caucasian man with a history of World Health Organization grade I hemangioblastoma of the cerebellar vermis underwent gross total resection in 1997. In early 2018, he developed intracranial recurrences with diffuse leptomeningeal disease of the entire spine. The patient underwent resection of intracranial recurrence, followed by palliative craniospinal irradiation. The disease progressed quickly, and he died 8 months after recurrence.
CONCLUSIONS: Despite a benign pathology, hemangioblastoma has a low risk of metastasis. The outcome for hemangioblastoma patients with metastasis is poor. Multidisciplinary care for patients with metastatic hemangioblastoma warrants further investigation, and an effective systemic option is urgently needed. Regular lifelong follow-up of at-risk patients is recommended.
Recommended Citation
Poiset, Spencer J.; Reddy, Aneesh; Tucker, Catherine M.; Kenyon, Lawrence C.; Judy, Kevin D.; and Shi, Wenyin, "Hemangioblastoma With Late Leptomeningeal Metastasis: A Case Report" (2023). Department of Radiation Oncology Faculty Papers. Paper 173.
https://jdc.jefferson.edu/radoncfp/173
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
36935497
Language
English
Comments
This article is the author's final published version in Journal of Medical Case Reports, Volume 17, 2023, Article number 102.
The published version is available at https://doi.org/10.1186/s13256-023-03812-5. Copyright © The Author(s) 2023.