Authors

Sarthak Pati, University of Pennsylvania
Ujjwal Baid, University of Pennsylvania
Brandon Edwards, Intel Corporation
Micah Sheller, Intel Corporation
Shih-Han Wang, Intel Corporation
G. Anthony Reina, Intel Corporation
Patrick Foley, Intel Corporation
Alexey Gruzdev, Intel Corporation
Deepthi Karkada, Intel Corporation
Christos Davatzikos, University of Pennsylvania
Chiharu Sako, University of Pennsylvania
Satyam Ghodasara, University of Pennsylvania
Michel Bilello, University of Pennsylvania
Suyash Mohan, University of Pennsylvania
Philipp Vollmuth, Heidelberg University Hospital
Gianluca Brugnara, Heidelberg University Hospital
Chandrakanth J. Preetha, Heidelberg University Hospital
Felix Sahm, Heidelberg University Hospital
Klaus Maier-Hein, Heidelberg University Hospital
Maximilian Zenk, German Cancer Research Center
Martin Bendszus, Heidelberg University Hospital
Wolfgang Wick, Heidelberg University Hospital
Evan Calabrese, University of California San Francisco
Jeffrey Rudie, University of California San Francisco
Javier Villanueva-Meyer, University of California San Francisco
Soonmee Cha, University of California San Francisco
Madhura Ingalhalikar, Symbiosis International University
Manali Jadhav, Symbiosis International University
Umang Pandey, Symbiosis International University
Jitender Saini, National Institute of Mental Health and Neurosciences
John Garrett, University of Wisconsin-Madison
Matthew Larson, University of Wisconsin-Madison
Robert Jeraj, University of Wisconsin-Madison
Stuart Currie, Leeds Teaching Hospitals Trust
Russell Frood, Leeds Teaching Hospitals Trust
Kavi Fatania, Leeds Teaching Hospitals Trust
Raymond Y. Huang, Harvard University
Ken Chang, Massachusetts General Hospital
Carmen Balaña Quintero, Catalan Institute of Oncology
Jaume Capellades, Barcelona MAR Health Park Consortium
Josep Puig, Josep Trueta University Hospital
Johannes Trenkler, Kepler University Hospital Linz
Josef Pichler, Kepler University Hospital Linz
Georg Necker, Kepler University Hospital Linz
Andreas Haunschmidt, Kepler University Hospital Linz
Stephan Meckel, Kepler University Hospital Linz
Gaurav Shukla, University of Pennsylvania
Spencer Liem, Thomas Jefferson University
Gregory S Alexander, University of Maryland
Joseph Lombardo, Thomas Jefferson UniversityFollow
Joshua D. Palmer, The Ohio State University
Adam E. Flanders, Thomas Jefferson University
Adam P. Dicker, Thomas Jefferson University
Haris I. Sair, Johns Hopkins University
Craig K. Jones, Johns Hopkins University
Archana Venkataraman, Johns Hopkins University
Meirui Jiang, The Chinese University of Hong Kong
Tiffany Y. So, The Chinese University of Hong Kong
Cheng Chen, The Chinese University of Hong Kong
Pheng Ann Heng, The Chinese University of Hong Kong
Qi Dou, The Chinese University of Hong Kong
Michal Kozubek, Masaryk University
Filip Lux, Masaryk University
Jan Michálek, Masaryk University
Petr Matula, Masaryk University
Miloš Keřkovský, Masaryk University
Tereza Kopřivová, Masaryk University
Marek Dostál, Masaryk University
Václav Vybíhal, Masaryk University
Michael A. Vogelbaum, H. Lee Moffitt Cancer Center and Research Institute
J. Ross Mitchell, University of Alberta
Joaquim Farinhas, H. Lee Moffitt Cancer Center and Research Institute
Joseph A. Maldjian, University of Texas Southwestern Medical Center
Chandan Ganesh Bangalore Yogananda, University of Texas Southwestern Medical Center
Marco C. Pinho, University of Texas Southwestern Medical Center
Divya Reddy, University of Texas Southwestern Medical Center
James Holcomb, University of Texas Southwestern Medical Center
Benjamin C. Wagner, University of Texas Southwestern Medical Center
Benjamin M. Ellingson, University of California Los Angeles
Timothy F. Cloughesy, University of California Los Angeles
Catalina Raymond, University of California Los Angeles
Talia Oughourlian, University of California Los Angeles
Akifumi Hagiwara, University of California Los Angeles
Chencai Wang, University of California Los Angeles
Minh-Son To, Flinders University
Sargam Bhardwaj, Flinders University
Chee Chong, Flinders University
Marc Agzarian, Flinders University
Alexandre Xavier Falcão, University of Campinas
Samuel B. Martins, Federal Institute of São Paulo
Bernardo C. A. Teixeira, Instituto de Neurologia de Curitiba
Flávia Sprenger, Hospital de Clínicas da Universidade Federal do Paraná
David Menotti, Universidade Federal do Paraná
Diego R. Lucio, Universidade Federal do Paraná
Pamela LaMontagne, Washington University in St. Louis
Daniel Marcus, Washington University in St. Louis
Benedikt Wiestler, Technical University of Munich
Florian Kofler, Technical University of Munich
Ivan Ezhov, Technical University of Munich
Marie Metz, Technical University of Munich
Rajan Jain, New York University School of Medicine
Matthew Lee, New York University School of Medicine
Yvonne W. Lui, New York University School of Medicine
Richard McKinley, University of Bern
Johannes Slotboom, University of Bern
Piotr Radojewski, University of Bern
Raphael Meier, University of Bern
Roland Wiest, University of Bern
Derrick Murcia, University of Colorado
Eric Fu, University of Colorado
Rourke Haas, University of Colorado
John Thompson, University of Colorado
David Ryan Ormond, University of Colorado
Chaitra Badve, University Hospitals Cleveland
Andrew E. Sloan, Case Western Reserve University
Vachan Vadmal, Case Western Reserve University
Kristin Waite, National Institute of Health
Rivka R. Colen, University of Pittsburgh
Linmin Pei, University of Pittsburgh Medical Center
Murat Ak, University of Pittsburgh
Ashok Srinivasan, University of Michigan
J. Rajiv Bapuraj, University of Michigan
Arvind Rao, University Of Michigan
Nicholas Wang, University of Michigan
Ota Yoshiaki, University of Michigan
Toshio Moritani, University of Michigan
Sevcan Turk, University of Michigan
Joonsang Lee, University of Michigan
Snehal Prabhudesai, University of Michigan
Fanny Morón, Baylor College of Medicine
Jacob Mandel, Baylor College of Medicine
Konstantinos Kamnitsas, Imperial College London
Ben Glocker, Imperial College London
Luke V. M. Dixon, Imperial College NHS Healthcare Trust,
Matthew Williams, Imperial College London
Peter Zampakis, University of Patras
Vasileios Panagiotopoulos, University of Patras
Panagiotis Tsiganos, University of Patras
Sotiris Alexiou, University of Patras
Ilias Haliassos, University of Patras
Evangelia I Zacharaki, University of Patras
Konstantinos Moustakas, University of Patras
Christina Kalogeropoulou, University of Patras
Dimitrios M. Kardamakis, University of Patras
Yoon Seong Choi, Yonsei University
Seung-Koo Lee, Yonsei University
Jong Hee Chang, Yonsei University
Sung Soo Ahn, Yonsei University
Bing Luo, Henry Ford Health System
Laila Poisson, Henry Ford Health System
Ning Wen, Henry Ford Health System
Pallavi Tiwari, Case Western Reserve University
Ruchika Verma, Case Western Reserve University
Rohan Bareja, Case Western Reserve University
Ipsa Yadav, Case Western Reserve University
Jonathan Chen, Case Western Reserve University
Neeraj Kumar, University of Alberta
Marion Smits, Erasmus MC University Medical Centre Rotterdam
Sebastian R. van der Voort, Erasmus MC University Medical Centre Rotterdam
Ahmed Alafandi, Erasmus MC University Medical Centre Rotterdam
Fatih Incekara, Erasmus MC University Medical Centre Rotterdam
Maarten M. J. Wijnenga, Erasmus MC Cancer Institute
Georgios Kapsas, Erasmus MC University Medical Centre Rotterdam
Renske Gahrmann, Erasmus MC University Medical Centre Rotterdam
Joost W Schouten, Erasmus MC University Medical Centre Rotterdam
Hendrikus J. Dubbink, Erasmus MC Cancer Institute
Arnaud J. P. E. Vincent, Erasmus MC University Medical Centre Rotterdam
Martin J. van den Bent, Erasmus MC Cancer Institute
Pim J. French, Erasmus MC Cancer Institute
Stefan Klein, Erasmus MC University Medical Centre Rotterdam
Yading Yuan, Mount Sinai School of Medicine
Sonam Sharma, Mount Sinai School of Medicine
Tzu-Chi Tseng, Mount Sinai School of Medicine
Saba Adabi, Mount Sinai School of Medicine
Simone P. Niclou, Luxembourg Institute of Health
Olivier Keunen, Luxembourg Institute of Health
Ann-Christin Hau, Luxembourg Institute of Health
Martin Vallières, Université de Sherbrooke
David Fortin, Université de Sherbrooke
Martin Lepage, Université de Sherbrooke
Bennett Landman, Vanderbilt University
Karthik Ramadass, Vanderbilt University
Kaiwen Xu, Vanderbilt University
Silky Chotai, Vanderbilt University
Lola B. Chambless, Vanderbilt University
Akshitkumar Mistry, Vanderbilt University
Reid C. Thompson, Vanderbilt University
Yuriy Gusev, Georgetown University
Krithika Bhuvaneshwar, Georgetown University
Anousheh Sayah, Georgetown University
Camelia Bencheqroun, Georgetown University
Anas Belouali, Georgetown University
Subha Madhavan, Georgetown University
Thomas C. Booth, King’s College London
Alysha Chelliah, King’s College London
Marc Modat, King’s College London
Haris Shuaib, Stoke Mandeville Hospital
Carmen Dragos, Stoke Mandeville Hospital
Aly Abayazeed, Neosoma Inc.
Kenneth Kolodziej, Neosoma Inc.
Michael Hill, Neosoma Inc.
Ahmed Abbassy, University of Cairo
Shady Gamal, University of Cairo
Mahmoud Mekhaimar, University of Cairo
Mohamed Qayati, University of Cairo
Mauricio Reyes, University of Bern
Ji Eun Park, Asan Medical Center
Jihye Yun, Asan Medical Center
Ho Sung Kim, Asan Medical Center
Abhishek Mahajan, The Clatterbridge Cancer Centre
Mark Muzi, University of Washington
Sean Benson, Netherlands Cancer Institute
Regina G. H. Beets-Tan, Netherlands Cancer Institute
Jonas Teuwen, Netherlands Cancer Institute
Alejandro Herrera-Trujillo, Universidad del Valle
Maria Trujillo, Universidad del Valle
William Escobar, Universidad del Valle
Ana Abello, Universidad del Valle
Jose Bernal, Universidad del Valle
Jhon Gómez, Universidad del Valle
Joseph Choi, University of Iowa
Stephen Baek, University of Iowa
Yusung Kim, University of Iowa
Heba Ismael, University of Iowa
Bryan Allen, University of Iowa
John M. Buatti, University of Iowa
Aikaterini Kotrotsou, University of Texas
Hongwei Li, University of Zurich
Tobias Weiss, University of Zurich
Michael Weller, University of Zurich
Andrea Bink, University of Zurich
Bertrand Pouymayou, University of Zurich
Hassan F. Shaykh, University of Alabama
Joel Saltz, Stony Brook University
Prateek Prasanna, Stony Brook University
Sampurna Shrestha, Stony Brook University
Kartik M. Mani, Stony Brook University
David Payne, Stony Brook University
Tahsin Kurc, Stony Brook University
Enrique Pelaez, Escuela Superior Politecnica del Litoral
Heydy Franco-Maldonado, Sociedad de Lucha Contral el Cancer
Francis Loayza, Escuela Superior Politecnica del Litoral
Sebastian Quevedo, Universidad Católica de Cuenca
Pamela Guevara, Universidad de Concepción
Esteban Torche, Universidad de Concepción
Cristobal Mendoza, Universidad de Concepción
Franco Vera, Universidad de Concepción
Elvis Ríos, Universidad de Concepción
Eduardo López, Universidad de Concepción
Sergio A. Velastin, Queen Mary University of London
Godwin Ogbole, University College Hospital Ibadan
Mayowa Soneye, University College Hospital Ibadan
Dotun Oyekunle, University College Hospital Ibadan
Olubunmi Odafe-Oyibotha, Clinix Healthcare
Babatunde Osobu, University College Hospital Ibadan
Mustapha Shu'aibu, Muhammad Abdullahi Wase Teaching Hospital
Adeleye Dorcas, Obafemi Awolowo University Ile-Ife
Farouk Dako, University of Pennsylvania
Amber L. Simpson, Queen’s University ON
Mohammad Hamghalam, Queen’s University ON
Jacob J. Peoples, Queen’s University ON
Ricky Hu, Queen’s University ON
Anh Tran, Queen’s University ON
Danielle Cutler, Queen’s University ON
Fabio Y. Moraes, Queen’s University ON
Michael A. Boss, American College of Radiology
James Gimpel, American College of Radiology
Deepak Kattil Veettil, American College of Radiology
Kendall Schmidt, American College of Radiology
Brian Bialecki, American College of Radiology
Sailaja Marella, American College of Radiology
Cynthia Price, American College of Radiology
Lisa Cimino, American College of Radiology
Charles Apgar, American College of Radiology
Prashant Shah, Intel Corporation
Bjoern Menze, Technical University of Munich
Jill S. Barnholtz-Sloan, National Institute of Health
Jason Martin, Intel Corporation
Spyridon Bakas, University of Pennsylvania

Document Type

Article

Publication Date

12-5-2022

Comments

This article is the author's final published version in Nature Communications, Volume 13, Issue 1, December 2022, Article number 7346.

The published version is available at https://doi.org/10.1038/s41467-022-33407-5. Copyright © The Author(s) 2022.

Abstract

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

36470898

Language

English

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