African American men with low-grade prostate cancer have increased disease recurrence after prostatectomy compared with Caucasian men.

Authors

Kosj Yamoah, Thomas Jefferson University
Curtiland Deville, University of Pennsylvania Perelman School of MedicineFollow
Neha Vapiwala, University of Pennsylvania Perelman School of Medicine
Elaine Spangler, University of Pennsylvania Perelman School of Medicine
Charnita M. Zeigler-Johnson, Thomas Jefferson UniversityFollow
Bruce Malkowicz, University of Pennsylvania Perelman School of Medicine
David I Lee, University of Pennsylvania Perelman School of Medicine
Michael Kattan, Cleveland Clinic
Adam P. Dicker, Thomas Jefferson UniversityFollow
Timothy R. Rebbeck, University of Pennsylvania Perelman School of MedicineFollow

Document Type

Article

Publication Date

2-1-2015

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Urologic oncology, Volume 33, Issue 2, January 2015, Pages 70.e15-22.

The published version is available at https://doi.org/10.1016/j.urolonc.2014.07.005 Copyright © Elsevier

Abstract

PURPOSE: To explore whether disparities in outcomes exist between African American (AA) and Caucasian (CS) men with low-grade prostate cancer and similar cancer of the prostate risk assessment-postsurgery (CAPRA-S) features following prostatectomy (RP).

METHODS: The overall cohort consisted of 1,265 men (234 AA and 1,031 CS) who met the National comprehensive cancer network criteria for low- to intermediate-risk prostate cancer and underwent RP between 1990 and 2012. We first evaluated whether clinical factors were associated with adverse pathologic outcomes and freedom from biochemical failure (FFbF) using the entire cohort. Next, we studied a subset of 705 men (112 AA and 593 CS) who had pathologic Gleason score≤6 (low-grade disease). Using this cohort, we determined whether race affected FFbF in men with RP-proven low-grade disease and similar CAPRA-S scores.

RESULTS: With a median follow-up time of 27 months, the overall 7-year FFbF rate was 86% vs. 79% in CS and AA men, respectively (P = 0.035). There was no significant difference in one or more adverse pathologic features between CS vs. AA men (27% vs. 31%; P = 0.35) or CAPRA-S score (P = 0.28). In the subset analysis of patients with low-grade disease, AA race was associated with worse FFbF outcomes (P = 0.002). Furthermore, AA race was a significant predictor of FFbF in men with low-grade disease (hazard ratio = 2.01, 95% CI: 1.08-3.72; P = 0.029).

CONCLUSIONS: AA race is a predictor of worse FFbF outcomes in men with low-grade disease after RP. These results suggest that a subset of AA men with low-grade disease may benefit from more aggressive treatment.

Recommended Citation

Yamoah, Kosj; Deville, Curtiland; Vapiwala, Neha; Spangler, Elaine; Zeigler-Johnson, Charnita M.; Malkowicz, Bruce; Lee, David I; Kattan, Michael; Dicker, Adam P.; and Rebbeck, Timothy R., "African American men with low-grade prostate cancer have increased disease recurrence after prostatectomy compared with Caucasian men." (2015). Department of Radiation Oncology Faculty Papers. Paper 101.
https://jdc.jefferson.edu/radoncfp/101

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

25304288

Language

English