Dynamic prostatic and laser-ablated lesion volume change after transperineal laser ablation in canine: preliminary observation and its clinical significance.

Authors

Rui-Qing Liu, Henan University People's Hospital, Zhengzhou City, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology
Ji-Bin Liu, Thomas Jefferson University HospitalFollow
Shao-Bo Duan, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Henan University People's Hospital, Zhengzhou City
Si-Guo Cheng, Henan University People's Hospital, Zhengzhou City
Zhi-Yang Chang, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Henan University People's Hospital, Zhengzhou City
Hui-Cun Cao, Henan University People's Hospital, Zhengzhou City
Guang-Shao Cao, Henan University People's Hospital, Zhengzhou City
Ya-Qiong Li, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology
Na Li, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Henan University People's Hospital, Zhengzhou City
Lian-Zhong Zhang, Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Henan University People's Hospital, Zhengzhou City

Document Type

Article

Publication Date

1-1-2020

Comments

This is the final published version of the article from International Journal of Hyperthermia, 2020;37(1):1260-1267.

The article can also be accessed at the journals website: https://doi.org/10.1080/02656736.2020.1842517

Copyright. The Authors.

Abstract

AIM: The purpose of this study is to observe the volume change of prostate and laser-ablated lesions in the canine and to explore the mechanism and clinical significance through histopathology.

MATERIALS AND METHODS: Transperineal laser ablation (TPLA) was performed under the guidance of transrectal ultrasound (TRUS) in eight canines. Two canines were sacrificed 1 day and 1 week after TPLA, respectively. The remaining six canines were sacrificed after finishing transrectal contrast-enhanced ultrasound (TR-CEUS) at three phases.

RESULTS: The prostatic volumes immediately following TPLA and 1 week later were larger than before TPLA (20.1 ± 3.9 vs 17.1 ± 3.8 ml; 21.7 ± 3.6 vs 17.1 ± 3.8 ml, p < 0.05), but 1 month later, returned to the preoperative level (17.4 ± 3.2 ml). At three time points, the mean volumes of laser-ablated lesions at 3 W/600 J were 0.6 ± 0.2, 1.1 ± 0.4, and 1.7 ± 0.5 ml, respectively, while those of laser-ablated lesions at 3 W/1200 J were 1.2 ± 0.2, 1.6 ± 0.3, and 2.2 ± 0.5 ml, respectively. The mean volumes of laser-ablated lesions increased significantly over time after TPLA (p < 0.050).

CONCLUSION: The prostate volume transient enlarges after TPLA, which prompts for clinical application that it should prolong appropriately the duration of urinary catheterization to avoid acute urinary retention. Many inflammatory cells were observed in the laser-ablated lesions and adjacent normal prostate parenchyma through histopathology. It is speculated that the inflammatory response is involved in the progression of tissue damage.

Recommended Citation

Liu, Rui-Qing; Liu, Ji-Bin; Duan, Shao-Bo; Cheng, Si-Guo; Chang, Zhi-Yang; Cao, Hui-Cun; Cao, Guang-Shao; Li, Ya-Qiong; Li, Na; and Zhang, Lian-Zhong, "Dynamic prostatic and laser-ablated lesion volume change after transperineal laser ablation in canine: preliminary observation and its clinical significance." (2020). Department of Radiology Faculty Papers. Paper 96.
https://jdc.jefferson.edu/radiologyfp/96

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

33191810

Language

English