Silent Sentence Completion Shows Superiority Localizing Wernicke's Area and Activation Patterns of Distinct Language Paradigms Correlate with Genomics: Prospective Study.

Authors

Kamel El Salek, University of Texas MD Anderson Cancer Center
Islam S. Hassan, University of Texas MD Anderson Cancer Center
Aikaterini Kotrotsou, University of Texas MD Anderson Cancer Center
Srishti Abrol, University of Texas MD Anderson Cancer Center
Scott H. Faro, Temple UniversityFollow
Feroze B. Mohamed, Thomas Jefferson UniversityFollow
Pascal O. Zinn, Baylor College of Medicine
Wei Wei, University of Texas MD Anderson Cancer CenterFollow
Nan Li, University of Texas MD Anderson Cancer Center
Ashok J. Kumar, University of Texas MD Anderson Cancer Center
Jeffrey S. Weinberg, University of Texas MD Anderson Cancer Center
Jeffrey S. Wefel, University of Texas MD Anderson Cancer CenterFollow
Shelli R. Kesler, University of Texas MD Anderson Cancer Center
Ho-Ling Anthony Liu, University of Texas MD Anderson Cancer Center
Ping Hou, University of Texas MD Anderson Cancer Center
R. Jason Stafford, University of Texas MD Anderson Cancer Center
Sujit Prabhu, University of Texas MD Anderson Cancer Center
Raymond Sawaya, University of Texas MD Anderson Cancer Center
Rivka R. Colen, University of Texas MD Anderson Cancer Center

Document Type

Article

Publication Date

12-1-2017

Comments

This article has been peer reviewed. It is the author’s final published version in Scientific Reports

Volume 7, Issue 1, December 2017, Article number 12054.

The published version is available at DOI: 10.1038/s41598-017-11192-2. Copyright © Salek et al.

Abstract

Preoperative mapping of language areas using fMRI greatly depends on the paradigms used, as different tasks harness distinct capabilities to activate speech processing areas. In this study, we compared the ability of 3 covert speech paradigms: Silent Sentence Completion (SSC), category naming (CAT) and verbal fluency (FAS), in localizing the Wernicke's area and studied the association between genomic markers and functional activation. Fifteen right-handed healthy volunteers and 35 mixed-handed patients were included. We focused on the anatomical areas of posterosuperior, middle temporal and angular gyri corresponding to Wernicke's area. Activity was deemed significant in a region of interest if P < 0.05. Association between fMRI activation and genomic mutation status was obtained. Results demonstrated SSC's superiority at localizing Wernicke's area. SSC demonstrated functional activity in 100% of cancer patients and healthy volunteers; which was significantly higher than those for FAS and CAT. Patients with 1p/19q non-co-deleted had higher extent of activation on SSC (P < 0.02). Those with IDH-1 wild-type were more likely to show no activity on CAT (P < 0.05). SSC is a robust paradigm for localizing Wernicke's area, making it an important clinical tool for function-preserving surgeries. We also found a correlation between tumor genomics and functional activation, which deserves more comprehensive study.

Recommended Citation

Salek, Kamel El; Hassan, Islam S.; Kotrotsou, Aikaterini; Abrol, Srishti; Faro, Scott H.; Mohamed, Feroze B.; Zinn, Pascal O.; Wei, Wei; Li, Nan; Kumar, Ashok J.; Weinberg, Jeffrey S.; Wefel, Jeffrey S.; Kesler, Shelli R.; Liu, Ho-Ling Anthony; Hou, Ping; Stafford, R. Jason; Prabhu, Sujit; Sawaya, Raymond; and Colen, Rivka R., "Silent Sentence Completion Shows Superiority Localizing Wernicke's Area and Activation Patterns of Distinct Language Paradigms Correlate with Genomics: Prospective Study." (2017). Department of Radiology Faculty Papers. Paper 51.
https://jdc.jefferson.edu/radiologyfp/51

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

28935966