Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from belarus exposed to radioiodines after the Chernobyl accident.

Lydia B Zablotska, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CaliforniaFollow
Eldar A Nadyrov, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
Alexander V Rozhko, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusFollow
Zhihong Gong, Roswell Park Cancer Institute, Buffalo, New York
Olga N Polyanskaya, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusFollow
Robert J McConnell, The Thyroid Center, Columbia University, New York, New YorkFollow
Patrick O'Kane, Radiology Department, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaFollow
Alina V Brenner, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow
Mark P Little, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Evgenia Ostroumova, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Andre Bouville, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow
Vladimir Drozdovitch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Viktor Minenko, Research Institute for Nuclear Problems, Minsk, BelarusFollow
Yuri Demidchik, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
Alexander Nerovnya, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
Vassilina Yauseyenka, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
Irina Savasteeva, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
Sergey Nikonovich, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
Kiyohiko Mabuchi, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Maureen Hatch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow

Document Type

Article

Publication Date

2-1-2015

Comments

This article has been peer reviewed. It was published in: Cancer.

Volume 121, Issue 3, 1 February 2015, Pages 457-466.

The published version is available at DOI: 10.1002/cncr.29073

Copyright © 2014 American Cancer Society

Abstract

BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.

METHODS: A cohort of 11,664 individuals in Belarus who were aged ≤18 years at the time of the accident underwent 3 cycles of thyroid screening during 1997 to 2008. I-131 thyroid doses were estimated from individual thyroid activity measurements taken within 2 months after the accident and from dosimetric questionnaire data. Demographic, clinical, and tumor pathologic characteristics of the patients with thyroid cancer were analyzed using 1-way analysis of variance, chi-square tests or Fisher exact tests, and logistic regression.

RESULTS: In total, 158 thyroid cancers were identified as a result of screening. The majority of patients had T1a and T1b tumors (93.7%), with many positive regional lymph nodes (N1; 60.6%) but few distant metastases (M1;

CONCLUSIONS: I-131 thyroid radiation doses were associated with a significantly greater frequency of solid and diffuse sclerosing variants of thyroid cancer and various features of tumor aggressiveness.

PubMed ID

25351557

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