Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from belarus exposed to radioiodines after the Chernobyl accident.

Authors

• Lydia B Zablotska, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CaliforniaFollow
• Eldar A Nadyrov, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
• Alexander V Rozhko, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusFollow
• Zhihong Gong, Roswell Park Cancer Institute, Buffalo, New York
• Olga N Polyanskaya, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusFollow
• Robert J McConnell, The Thyroid Center, Columbia University, New York, New YorkFollow
• Patrick O'Kane, Radiology Department, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaFollow
• Alina V Brenner, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow
• Mark P Little, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
• Evgenia Ostroumova, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
• Andre Bouville, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow
• Vladimir Drozdovitch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
• Viktor Minenko, Research Institute for Nuclear Problems, Minsk, BelarusFollow
• Yuri Demidchik, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
• Alexander Nerovnya, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus
• Vassilina Yauseyenka, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
• Irina Savasteeva, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
• Sergey Nikonovich, The Republican Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus
• Kiyohiko Mabuchi, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
• Maureen Hatch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MarylandFollow

Document Type

Article

Publication Date

2-1-2015

Comments

This article has been peer reviewed. It was published in: Cancer.

Volume 121, Issue 3, 1 February 2015, Pages 457-466.

The published version is available at DOI: 10.1002/cncr.29073

Copyright © 2014 American Cancer Society

Abstract

BACKGROUND: Recent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.

METHODS: A cohort of 11,664 individuals in Belarus who were aged ≤18 years at the time of the accident underwent 3 cycles of thyroid screening during 1997 to 2008. I-131 thyroid doses were estimated from individual thyroid activity measurements taken within 2 months after the accident and from dosimetric questionnaire data. Demographic, clinical, and tumor pathologic characteristics of the patients with thyroid cancer were analyzed using 1-way analysis of variance, chi-square tests or Fisher exact tests, and logistic regression.

RESULTS: In total, 158 thyroid cancers were identified as a result of screening. The majority of patients had T1a and T1b tumors (93.7%), with many positive regional lymph nodes (N1; 60.6%) but few distant metastases (M1;

CONCLUSIONS: I-131 thyroid radiation doses were associated with a significantly greater frequency of solid and diffuse sclerosing variants of thyroid cancer and various features of tumor aggressiveness.

Recommended Citation

Zablotska, Lydia B; Nadyrov, Eldar A; Rozhko, Alexander V; Gong, Zhihong; Polyanskaya, Olga N; McConnell, Robert J; O'Kane, Patrick; Brenner, Alina V; Little, Mark P; Ostroumova, Evgenia; Bouville, Andre; Drozdovitch, Vladimir; Minenko, Viktor; Demidchik, Yuri; Nerovnya, Alexander; Yauseyenka, Vassilina; Savasteeva, Irina; Nikonovich, Sergey; Mabuchi, Kiyohiko; and Hatch, Maureen, "Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from belarus exposed to radioiodines after the Chernobyl accident." (2015). Department of Radiology Faculty Papers. Paper 40.
https://jdc.jefferson.edu/radiologyfp/40

PubMed ID

25351557