Document Type
Article
Publication Date
12-31-2012
Abstract
OBJECTIVES: To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type.
MATERIALS AND METHODS: Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates.
RESULTS: RTE detected 6/62 cancer lesions with a maximum diameter of 0-5 mm (9.7%), 10/37 with a maximum diameter of 6-10 mm (27%), 24/34 with a maximum diameter of 11-20 20 mm (70.6%), 14/14 with a maximum diameter of >20 mm (100%) and 40/48 with a volume ≥0.2 cm(3) (83.3%). Regarding cancer lesions with a volume ≥ 0.2 cm³ there was a significant difference in PCa detection rates between Gleason scores with predominant Gleason pattern 3 compared to those with predominant Gleason pattern 4 or 5 (75% versus 100%; P = 0.028).
CONCLUSIONS: RTE is able to detect PCa of significant tumor volume and of predominant Gleason pattern 4 or 5 with high confidence, but is of limited value in the detection of small cancer lesions.
Recommended Citation
Junker, Daniel; Schäfer, Georg; Aigner, Friedrich; Schullian, Peter; Pallwein-Prettner, Leo; Bektic, Jasmin; Horninger, Wolfgang; Halpern, Ethan J; and Frauscher, Ferdinand, "Potentials and limitations of real-time elastography for prostate cancer detection: a whole-mount step section analysis." (2012). Department of Radiology Faculty Papers. Paper 29.
https://jdc.jefferson.edu/radiologyfp/29
PubMed ID
23346015
Comments
This article has been peer reviewed. It was published in: Scientific World Journal.
2012;2012:193213.
The published version is available at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549343/?report=classic DOI: 10.1100/2012/193213.
Copyright © 2012 Daniel Junker et al.