Document Type
Article
Publication Date
6-29-2023
Abstract
Objective: To evaluate two different dual-energy computed tomography (DECT) post-processing protocols for the detection of MSU deposits in foot tendons of cadavers with verification by polarizing light microscopy as the gold standard. Material and Methods: A total of 40 embalmed cadavers (15 male; 25 female; median age, 82 years; mean, 80 years; range, 52–99; SD ± 10.9) underwent DECT to assess MSU deposits in foot tendons. Two postprocessing DECT protocols with different Hounsfield unit (HU) thresholds, 150/500 (=established) versus 120/500 (=modified). HU were applied to dual source acquisition with 80 kV for tube A and 140 kV for tube B. Six fresh cadavers (4 male; 2 female; median age, 78; mean, 78.5; range 61–95) were examined by DECT. Tendon dissection of 2/6 fresh cadavers with positive DECT 120 and negative DECT 150 studies were used to verify MSU deposits by polarizing light microscopy. Results: The tibialis anterior tendon was found positive in 57.5%/100% (DECT 150/120), the peroneus tendon in 35%/100%, the achilles tendon in 25%/90%, the flexor halluces longus tendon in 10%/100%, and the tibialis posterior tendon in 12.5%/97.5%. DECT 120 resulted in increased tendon MSU deposit detection, when DECT 150 was negative, with an overall agreement between DECT 150 and DECT 120 of 80% (p = 0.013). Polarizing light microscope confirmed MSU deposits detected only by DECT 120 in the tibialis anterior, the achilles, the flexor halluces longus, and the peroneal tendons. Conclusion: The DECT 120 protocol showed a higher sensitivity when compared to DECT 150.
Recommended Citation
Klauser, Andrea Sabine; Strobl, Sylvia; Schwabl, Christoph; Kremser, Christian; Klotz, Werner; Nikodinovska, Violeta Vasilevska; Stofferin, Hannes; Scharll, Yannick; and Halpern, Ethan, "Impact of Dual-Energy Computed Tomography (DECT) Postprocessing Protocols on Detection of Monosodium Urate (MSU) Deposits in Foot Tendons of Cadavers" (2023). Department of Radiology Faculty Papers. Paper 152.
https://jdc.jefferson.edu/radiologyfp/152
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in Diagnostics, Volume 13, Issue 13, 2023, Article number 2208.
The published version is available at https://doi.org/10.3390/diagnostics13132208. Copyright © 2023 by the authors. Licensee MDPI, Basel, Switzerland.