Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches.

Authors

Lauren J Delaney, Department of Radiology, Thomas Jefferson University, 132 S. 10th Street, Main 763, Philadelphia, 19107, PA, United States
Selin Isguven, Department of Radiology, Thomas Jefferson University, 132 S. 10th Street, Main 763, Philadelphia, 19107, PA, United States; Department of Orthopaedic Surgery, 1015 Walnut Street, Thomas Jefferson University, Philadelphia, 19107, PA, United States
John R Eisenbrey, Department of Radiology, Thomas Jefferson University, 132 S. 10th Street, Main 763, Philadelphia, 19107, PA, United States
Noreen J Hickok, Department of Orthopaedic Surgery, 1015 Walnut Street, Thomas Jefferson University, Philadelphia, 19107, PA, United States
Flemming Forsberg, Department of Radiology, Thomas Jefferson University, 132 S. 10th Street, Main 763, Philadelphia, 19107, PA, United States

Document Type

Article

Publication Date

4-4-2022

Comments

This article is the author's final published version in Materials Advances, Volume 3, Issue 7, February 2022, Pages 3023 - 3040.

The published version is available at https://doi.org/10.1039/d1ma01197a.

Copyright © 2022 The Author(s).

This article is licensed under a Creative Commons Attribution 3.0 Unported License.

Abstract

Administration of drugs through oral and intravenous routes is a mainstay of modern medicine, but this approach suffers from limitations associated with off-target side effects and narrow therapeutic windows. It is often apparent that a controlled delivery of drugs, either localized to a specific site or during a specific time, can increase efficacy and bypass problems with systemic toxicity and insufficient local availability. To overcome some of these issues, local delivery systems have been devised, but most are still restricted in terms of elution kinetics, duration, and temporal control. Ultrasound-targeted drug delivery offers a powerful approach to increase delivery, therapeutic efficacy, and temporal release of drugs ranging from chemotherapeutics to antibiotics. The use of ultrasound can focus on increasing tissue sensitivity to the drug or actually be a critical component of the drug delivery. The high spatial and temporal resolution of ultrasound enables precise location, targeting, and timing of drug delivery and tissue sensitization. Thus, this noninvasive, non-ionizing, and relatively inexpensive modality makes the implementation of ultrasound-mediated drug delivery a powerful method that can be readily translated into the clinical arena. This review covers key concepts and areas applied in the design of different ultrasound-mediated drug delivery systems across a variety of clinical applications.

Recommended Citation

Delaney, Lauren J; Isguven, Selin; Eisenbrey, John R; Hickok, Noreen J; and Forsberg, Flemming, "Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches." (2022). Department of Radiology Faculty Papers. Paper 124.
https://jdc.jefferson.edu/radiologyfp/124

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

PubMed ID

35445198

Language

English