Implications of the New ICSD-3 Diagnostic Criteria for Narcolepsy in Patients Diagnosed by ICSD-2

Authors

John Konikkara, MD, Department of Sleep Medicine, Thomas Jefferson University Hospital, Philadelphia, PAFollow
Robert Tavella, MPH, RPSGT, Department of Sleep Medicine, Thomas Jefferson University Hospital, Philadelphia, PAFollow
William Breuninger, RPSGT, Department of Sleep Medicine, Thomas Jefferson University Hospital, Philadelphia, PAFollow
Karl Doghramji, MD, Department of Sleep Medicine, Thomas Jefferson University Hospital, Philadelphia, PAFollow

Document Type

Poster

Publication Date

6-9-2015

Comments

Presented at American Academy of Sleep Medicine in Seattle Washington.

Abstract

BACKGROUND

The ICSD-2 diagnostic criteria for narcolepsy mandated 2 sleep-onset REM periods (SOREMPs) on multiple sleep latency testing (MSLT). Subsequent data suggested that a SOREMP within 15 minutes of nocturnal sleep onset, in the absence of another sleep disorder, is a highly specific finding for narcolepsy, but with low sensitivity. Therefore, the diagnostic criteria for the ICSD-3 allow for a minimum of one SOREMP during the MSLT, provided that the preceding overnight polysomnogram (PSG) also exhibits 1 SOREMP. We sought to re-evaluate the effects of this revision on diagnostic sensitivity by retrospectively applying ICSD-3 diagnostic criteria to patients who had achieved one SOREMP during the MSLT. We also examined the nocturnal PSG predictors of SOREMPs during the subsequent MSLT.

Recommended Citation

Konikkara, MD, John; Tavella, MPH, RPSGT, Robert; Breuninger, RPSGT, William; and Doghramji, MD, Karl, "Implications of the New ICSD-3 Diagnostic Criteria for Narcolepsy in Patients Diagnosed by ICSD-2" (2015). Department of Psychiatry and Human Behavior Faculty Papers. Paper 23.
https://jdc.jefferson.edu/phbfp/23