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Solid organ transplant recipients commonly require anticoagulation. Apixaban (APX) is principally metabolized by CYP3A4, undergoes direct intestinal excretion, and is a substrate to P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) transporters. We examined the potential drug interaction between cyclosporine (CsA) and tacrolimus (Tac) [combined inhibitors of CYP3A4, P-gp and, BCRP] with APX.
apixaban, cyclosporine, tacrolimus, transplantation
Medical Pharmacology | Medicine and Health Sciences
Bashir, MD, Babar; Tran, PharmD, Benjamin D.; Mantravadi, MD, Santhi; Stickle, PhD, Douglas F.; Chervoneva, PhD, Inna; and Kraft, MD, Walter K., "Drug Interaction Study Of Apixaban With Cyclosporine Or Tacrolimus: Results From A Phase 1, Randomized, Open-Label, Crossover Study In Healthy Volunteers" (2018). Department of Pharmacology and Experimental Therapeutics Posters. 5.