Document Type


Publication Date



This article has been peer reviewed. It is the authors' final version prior to publication in FEBS Journal

Volume 276, Issue 8, April 2009, Pages 2157-2164.

The published version is available at DOI: 10.1111/j.1742-4658.2009.06934.x. Copyright © John Wiley & Sons, Inc.


There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.

FEBS Fig 1_111708.pdf (55 kB)
Figure 1

FEBS Fig 2_111708.pdf (71 kB)
Figure 2

PubMed ID




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.