Overexpression of matrix metalloproteinase 9 in tumor epithelial cells correlates with colorectal cancer metastasis.

Authors

David S Zuzga, Thomas Jefferson UniversityFollow
Ahmara Vivian Gibbons, Thomas Jefferson UniversityFollow
Peng Li, Thomas Jefferson UniversityFollow
Wilhelm Johannes Lubbe, Thomas Jefferson UniversityFollow
Inna Chervoneva, Thomas Jefferson UniversityFollow
Giovanni Mario Pitari, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

9-1-2008

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Clinical and Translational Science

Volume 1, Issue 2, 2008, Pages 136-141

The published version is available at DOI: 10.1111/j.1752-8062.2008.00037.x. Copyright © Wiley

Abstract

Colorectal cancer mortality largely reflects metastasis, the spread of the disease to distant organs. Matrix metalloproteinase 9 (MMP-9) is a key regulator of metastasis and a target for anticancer strategies in colon cancer. Here, the overexpression of MMP-9 in pure tumor epithelial, but nor stromal, cell populations was associated with metastatic progression of colorectal cancer, as defined by reverse transcriptase-polymerase chain reaction (qRT-PCR) and confirmed by immunostaining. Thus, cancer cell MMP-9 represents a novel, selective prognostic and predictive factor that may be exploited for more effective disease stage stratification and therapeutic regimen selection in patients with colorectal cancer.

Recommended Citation

Zuzga, David S; Gibbons, Ahmara Vivian; Li, Peng; Lubbe, Wilhelm Johannes; Chervoneva, Inna; and Pitari, Giovanni Mario, "Overexpression of matrix metalloproteinase 9 in tumor epithelial cells correlates with colorectal cancer metastasis." (2008). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 27.
https://jdc.jefferson.edu/petfp/27

PubMed ID

20443834