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This is the presentation given for the 2001 Presidential Trainee Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics. An abstract of the presentation has been published in Clin. Pharmacol. Ther., 69(2):P62, 2001. The presentation illustrates the role of the intestinal GC-C receptor as a negative regulator of cell proliferation and cell cycle kinetics in colorectal cancer. It suggests that paracrine GC-C hormones guanylin/uroguanylin are physiological inducers of the proliferation-to-differentiation transition along the intestinal crypt-villus axis. Importantly, the bacterial enterotoxin ST, a potent exogenous GC-C agonist, is offered as a potential cytostatic agent for the prevention and treatment of colorectal cancer in patients.

Questa presentazione e’ stata effettuata in occasione del Premio 2001 Presidential Trainee Young Investigator della Societa’ Americana di Farmacologia e Terapia Clinica. La presentazione suggerisce per la prima volta che il recettore intestinale guanilato ciclasi C (GC-C o GCC) ed i suoi ligandi (guanilina, uroguanilina, ST) sono regolatori citostatici della proliferazione delle cellule intestinali, che possono essere utilizzati per la prevenzione e cura del cancro del coloretto.



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