Document Type
Article
Publication Date
8-11-2025
Abstract
OBJECTIVE: Development and validation of a clinical prediction model for receipt of pharmacotherapy for Neonatal Abstinence Syndrome (NAS).
STUDY DESIGN: Data from three cohorts included
RESULTS: Of 698 infants included, 430 received pharmacotherapy. The final model included seven predictors of receipt of pharmacotherapy: gestational age, exposure to maternal breast milk, type of maternal opioid medication, and exposure to heroin, cocaine, benzodiazepines, and/or antipsychotic medications. The model had an AUROC of 0.68 (95% CI: 0.64-0.72; optimism corrected 0.65).
CONCLUSION: Our prediction model was parsimonious and identified seven predictors associated with the need for PT. Larger cohort studies are needed to more definitively establish risk of significant NAS requiring pharmacotherapy.
Recommended Citation
Bibi, Shawana; Singh, Rachana; Breeze, Janis L.; Nelson, Jason; Kraft, Walter K.; and Davis, Jonathan M., "Clinical and Demographic Predictors of the Need for Pharmacotherapy in Neonatal Abstinence Syndrome" (2025). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 159.
https://jdc.jefferson.edu/petfp/159
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
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PubMed ID
40861052
Language
English
Comments
This article is the author's final published version in Frontiers in Pediatrics, Volume 13, August 2025, Article number 1527276.
The published version is available at https://doi.org/10.3389/fped.2025.1527276. Copyright © 2025 Bibi, Singh, Breeze, Nelson, Kraft and Davis.