Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants.
OBJECTIVE: To investigate the association between leukocytosis, mortality and bronchopulmonary dysplasia (BPD) in very-low-birth-weight infants (VLBW) born to mothers with histological chorioamnionitis.
STUDY DESIGN: A retrospective cohort study from a single level 3 neonatal intensive care unit. The study sample included infants born to mothers with histological chorioamnionitis (n=252). Total white blood cells (WBCs) after birth were measured. Leukocytosis was defined as a total WBC count >30 000 per mm(3) in the first 2 days of life. Outcomes investigated included BPD and death. Both unadjusted and multivariable analyses were carried out.
RESULT: After controlling for potential confounding variables, infants who developed a leukocytosis after birth had increased odds of BPD (4.6, 95% confidence interval (95% CI): 2.0 to 10.3), but decreased odds of death (0.3, 95% CI: 0.1 to 0.90).
CONCLUSION: In our population of VLBW infants born to mothers with histological chorioamnionitis, leukocytosis after birth is associated with a decrease in mortality but an increase in BPD.
Paul, MD, David A.; Zook, MD, Kelly; Mackley, RNC, Amy; and Locke, DO, Robert G., "Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants." (2010). Department of Pediatrics Faculty Papers. Paper 22.
This article has been peer reviewed. It is the authors' final version prior to publication in Journal of Perinatology Volume 30, Issue 1, January 2010, Pages 58-62. The published version is available at DOI: 10.1038/jp.2009.113. Copyright © Nature Publishing Group