Document Type
Article
Publication Date
4-12-2024
Abstract
Coronary microvascular dysfunction (CMD) encompasses a spectrum of structural and functional alterations in coronary microvasculature resulting in impaired coronary blood flow and consequent myocardial ischemia without obstruction in epicardial coronary artery. The pathogenesis of CMD is complex involving both functional and structural alteration in the coronary microcirculation. In adults, CMD is predominantly discussed in context with anginal chest pain or existing ischemic heart disease and its risk factors. The presence of CMD suggests increased risk of adverse cardiovascular events independent of coronary atherosclerosis. Coronary microvascular dysfunction is also known in children but is rarely recognized due to paucity of concommitent coronary artery disease. Thus, its clinical presentation, underlying mechanism of impaired microcirculation, and prognostic significance are poorly understood. In this review article, we will overview variable CMD reported in children and delineate its emerging clinical significance.
Recommended Citation
Tsuda, Takeshi and Patel, Gina, "Coronary Microvascular Dysfunction in Childhood: An Emerging Pathological Entity and Its Clinical Implications" (2024). Department of Pediatrics Faculty Papers. Paper 154.
https://jdc.jefferson.edu/pedsfp/154
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
38680649
Language
English
Comments
This article is the author's final published version in American Heart Journal Plus: Cardiology Research and Practice, Volume 42, 2024, Article number 100392.
The published version is available at https://doi.org/10.1016/j.ahjo.2024.100392.
Copyright © 2024 The Authors