Start Date
5-15-2025 9:30 AM
End Date
5-15-2025 11:30 AM
Description
Background
- Breast cancer is the most common non-cutaneous malignancy affecting women in the United States, with a lifetime incidence of nearly 13%
- The incidence of female breast cancer is rising, especially for young women (age < 45)
- While only 5-10% of breast cancers in the general population are related to highly penetrant pathogenic germline mutations, pathogenic mutations in BRCA1, BRCA2, CHEK2, PALB2, BARD1, and ATM occur at higher frequency in women diagnosed age < 50 years
- Mutations in BRCA1, BRCA2, and TP53 account for nearly 50% of breast cancers diagnosed before age 30
- Women < 40 years old breast cancer have worse disease-related survival, especially from to early-stage disease
Keywords
breast cancer, social vulnerability, health related social needs, social determinants of health, young adult oncology
Included in
Social Vulnerability and Health-Related Social Need Disparities Amongst Young Adults With Breast Cancer
Background
- Breast cancer is the most common non-cutaneous malignancy affecting women in the United States, with a lifetime incidence of nearly 13%
- The incidence of female breast cancer is rising, especially for young women (age < 45)
- While only 5-10% of breast cancers in the general population are related to highly penetrant pathogenic germline mutations, pathogenic mutations in BRCA1, BRCA2, CHEK2, PALB2, BARD1, and ATM occur at higher frequency in women diagnosed age < 50 years
- Mutations in BRCA1, BRCA2, and TP53 account for nearly 50% of breast cancers diagnosed before age 30
- Women < 40 years old breast cancer have worse disease-related survival, especially from to early-stage disease
Comments
Presented at the 2025 Jefferson Health Equity and Quality Improvement (HEQI) Summit.