BCL2 Expression and BCL2/MYC Dual Expression Predicts Inferior Survival in Primary Central Nervous System Lymphoma

Authors

Guldeep Uppal, MD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityFollow
Zi-Xuan (Zoe) Wang, PhD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityFollow
Renu Bajaj, PhD, Cytogenetics Laboratory, Departments of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital; Molecular Cytogenetics Laboratory, Department of Genetics, Yale University School of MedicineFollow
Mark T. Curtis, MD, PhD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson UniversityFollow
Charalambos C. Solomides, MD, Thomas Jefferson University HospitalFollow
Jon Glass, MD, Jefferson Hospital for Neuroscience, Thomas Jefferson UniversityFollow
Peter M. Banks, Scientific Affairs, Ventana Medical Systems
Stephen C. Peiper, MD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of AmericaFollow
Jerald Z. Gong, MD, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

4-2014

Abstract

Background

Primary CNS lymphoma (PCNSL) is a rare type of diffuse large B-cell lymphoma (DLBCL) arising from and usually confined to CNS. Understating of the pathogenesis and prognostic markers is a challenge due to rarity of this neoplasm and paucity of the material available to study. Recent studies have shown that dual expression of MYC and BCL2 in DLBCL contributes to inferior overall survival. The prognostic value of MYC and BCL2 in PCNSL is not well studied.

Recommended Citation

Uppal, MD, Guldeep; Wang, PhD, Zi-Xuan (Zoe); Bajaj, PhD, Renu; Curtis, MD, PhD, Mark T.; Solomides, MD, Charalambos C.; Glass, MD, Jon; Banks, Peter M.; Peiper, MD, Stephen C.; and Gong, MD, Jerald Z., "BCL2 Expression and BCL2/MYC Dual Expression Predicts Inferior Survival in Primary Central Nervous System Lymphoma" (2014). Department of Pathology, Anatomy, and Cell Biology Resident's Posters. Paper 5.
https://jdc.jefferson.edu/pacbresidentposters/5