Calcium uptake hotspots in the mitochondria of cardiac muscle at the interface with dyadic SR

Authors

Sergio De La Fuente, Thomas Jefferson UniversityFollow
Celia Fernandez-Sanz, Thomas Jefferson UniversityFollow
Caitlin Vail, Thomas Jefferson UniversityFollow
Elorm J. Agra, Thomas Jefferson UniversityFollow
Kira Holmstrom, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MDFollow
Junhui Sun, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MDFollow
Jyotsna Mishra, Thomas Jefferson UniversityFollow
Toren Finkel, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MDFollow
Elizabeth Murphy, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MDFollow
Suresh K. Joseph, Thomas Jefferson UniversityFollow
Shey-Shing Sheu, Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Thomas Jefferson UniversityFollow
György Csordás, Thomas Jefferson UniversityFollow

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Description

Introduction

• Control of the mitochondrial ATP production by SR-derived Ca2+ signals includes local, nanodomain Ca2+ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).

• Ca2+ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca2+-activated Ca2+ channel complex.

• The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).

Publication Date

12-15-2016

Keywords

Calcium uptake hotspots in the mitochondria of cardiac muscle at the interface with dyadic SR, Thomas Jefferson University, pathology, cell biology, anatomy

Disciplines

Medical Anatomy | Medical Cell Biology | Medical Pathology

Recommended Citation

De La Fuente, Sergio; Fernandez-Sanz, Celia; Vail, Caitlin; Agra, Elorm J.; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Finkel, Toren; Murphy, Elizabeth; Joseph, Suresh K.; Sheu, Shey-Shing; and Csordás, György, "Calcium uptake hotspots in the mitochondria of cardiac muscle at the interface with dyadic SR" (2016). Department of Pathology, Anatomy, and Cell Biology Posters. 7.
https://jdc.jefferson.edu/pacbposters/7