Use of Propensity Score Matching to Identify a Strong Association Between Strategic concentration to mitochondria-SR associations of the mitochondrial Ca2+ uniporter: Ca2+ uptake hotspots in the cardiac mitochondria

Authors

Sergio De La Fuente, MitoCare Center, Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
Caitlin Vail, MitoCare Center, Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USAFollow
Elorm J. Agra, MitoCare Center, Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USAFollow
Kira Holmstrom, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MD, USAFollow
Junhui Sun, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MD, USAFollow
Jyotsna Mishra, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USAFollow
Toren Kinkel, Center for Molecular Medicine, Lab. of Molecular Biology, NIH-NHLBI, Bethesda, MD, USA
Elizabeth Murphy, Systems Biology Center, Laboratory of Cardiac Physiology, NIH-NHLBI, Bethesda, MD, USA,Follow
Suresh K. Joseph, MitoCare Center, Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USAFollow
Shey-Shing Shen, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA
György Csordás, MitoCare Center, Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USAFollow

Files

Description

Introduction:

• Control of the mitochondrial ATP production by SR-derived Ca²⁺ signals includes local, nanodomain Ca²⁺ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling).
• Ca²⁺ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca²⁺-activated Ca²⁺ channel complex.
• The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).

Publication Date

4-3-2016

Keywords

Use of Propensity Score Matching to Identify a Strong Association Between Strategic concentration to mitochondria-SR associations of the mitochondrial Ca2+ uniporter: Ca2+ uptake hotspots in the cardiac mitochondria, Thomas Jefferson University, poster, Pathology, Anatomy and Cell Biology

Disciplines

Medical Anatomy | Medical Cell Biology | Medical Pathology

Comments

Presented at: 2016 Keystone Symposia-Mitochondrial Dynamics in Colorado.

Recommended Citation

Fuente, Sergio De La; Vail, Caitlin; Agra, Elorm J.; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Kinkel, Toren; Murphy, Elizabeth; Joseph, Suresh K.; Shen, Shey-Shing; and Csordás, György, "Use of Propensity Score Matching to Identify a Strong Association Between Strategic concentration to mitochondria-SR associations of the mitochondrial Ca2+ uniporter: Ca2+ uptake hotspots in the cardiac mitochondria" (2016). Department of Pathology, Anatomy, and Cell Biology Posters. 3.
https://jdc.jefferson.edu/pacbposters/3