Document Type
Article
Publication Date
6-3-2025
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) causes considerable morbidity and mortality in both community-acquired and healthcare-associated infections, but detecting colonization with MRSA has been shown to improve patient outcomes in certain clinical settings. MRSA colonization detection has been carried out in a variety of ways, with molecular assays having superior sensitivity in most studies relative to culture, but culture is disadvantaged in some comparisons by utilization of low specimen volumes. We compared a commercial molecular assay to both low-volume (10 µl) and high-volume (650 µl) cultures and found that increasing the volume utilized for culture led to the detection of 25% more cases than low-volume culture.
Recommended Citation
Mitchell, Arvette E.; Patel, Arpit P.; DiCandilo, Jennifer; Rebollido, Zachary W.; and Pettengill, Matthew, "Culture Harder: Use More Specimen to Increase Methicillin-Resistant Staphylococcus Aureus Culture Yield Relative to PCR" (2025). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 447.
https://jdc.jefferson.edu/pacbfp/447
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
40475911
Language
English
Comments
This article is the author's final published version in Access Microbiology, Volume 7, Issue 6, June 2025, Article number acmi.0.000918.v4.
The published version is available at https://doi.org/10.1099/acmi.0.000918.v4. Copyright © The Author(s).
Erratum issued June 30 2025: https://doi.org/10.1099/acmi.0.001063.