Anthropometric Measurements Inform Complete Concentric Collapse Status in Patients With Obstructive Sleep Apnea

Authors

• Jordan Weiner
• Eugene Chio
• Raj Dedhia
• Colin Huntley, Thomas Jefferson UniversityFollow
• Michael Hutz
• Phillip Huyett
• Daniel Lee
• Philip LoSavio
• Ilya Perepelitsyn
• Ryan Soose
• David Kent

Document Type

Article

Publication Date

5-5-2026

Comments

This article is the author’s final published version in OTO Open, Volume 10, Issue 2, 2026, Article number e70245.

The published version is available at https://doi.org/10.1002/oto2.70245. Copyright © 2026 The Author(s).

Abstract

OBJECTIVE: Hypoglossal nerve stimulation in the US requires drug-induced sleep endoscopy to exclude patients with complete concentric collapse. This is an expensive and time-consuming requirement. We hypothesized that supine pharyngeal width, and other demographic and polysomnographic variables would associate with complete concentric collapse.

STUDY DESIGN: Prospective, multicenter cohort study.

SETTING: 10 centers in the United States with experience selecting patients for and performing airway surgeries for sleep apnea including hypoglossal nerve stimulation implantation.

METHODS: 600 patients meeting criteria for hypoglossal nerve stimulation underwent measurement of supine pharyngeal width and collection of demographic and polysomnographic data followed by drug-induced sleep endoscopy.

RESULTS: 587 patients completed the study. Patients with complete concentric collapse had a higher body mass index (31.2 ± 3.2 vs 29.0 ± 3.4 kg/m², P < .001), larger neck circumference (45.5 ± 4.2 vs 40.6 ± 4.7 cm, P < .001), and lower supine pharyngeal width (19.4 ± 6.3 vs 21.8 ± 6.5 mm; P = .008) than patients without complete concentric collapse.

CONCLUSION: Body mass index, neck circumference, and supine pharyngeal width all associate with complete concentric collapse and could potentially be used to determine hypoglossal nerve stimulation candidacy instead of drug-induced sleep endoscopy for most patients thereby reducing both time and cost. (ClinicalTrials.gov NCT05428839: https://clinicaltrials.gov/study/NCT05428839?term=Inspire%20Medical%20systems%20predictor&rank=1).

Recommended Citation

Weiner, Jordan; Chio, Eugene; Dedhia, Raj; Huntley, Colin; Hutz, Michael; Huyett, Phillip; Lee, Daniel; LoSavio, Philip; Perepelitsyn, Ilya; Soose, Ryan; and Kent, David, "Anthropometric Measurements Inform Complete Concentric Collapse Status in Patients With Obstructive Sleep Apnea" (2026). Department of Otolaryngology - Head and Neck Surgery Faculty Papers. Paper 112.
https://jdc.jefferson.edu/otofp/112

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

42095116

Language

English