Document Type

Article

Publication Date

12-28-2025

Comments

This article is the author's final published version in International Journal of Spine Surgery, Volume 19, Issue 6, December 2025, Pages 710-721.

The published version is available at https://doi.org/10.14444/8837. Copyright © 2025 ISASS.

Abstract

BACKGROUND: Regenerative and wellness medicine is rapidly reshaping health care, particularly in the management of degenerative spine conditions. Noninvasive or minimally invasive options such as stem cell therapy, platelet-rich plasma (PRP) injections, and holistic wellness programs are increasingly selected by patients who wish to avoid the risks, costs, and prolonged recovery associated with elective spine surgery.

PURPOSE: This perspective article examines whether regenerative and wellness approaches function primarily as a boon or a barrier to innovation in spine surgery and explores their impact on traditional, insurance-based surgical care models.

METHODS: Using a narrative, opinion-based framework, this article synthesizes current trends in regenerative and wellness treatments, their economic growth relative to conventional spine care, and their penetration into nonsurgical spine markets. It further considers how these trends intersect with policy, reimbursement, and professional society initiatives.

RESULTS: The rapid expansion of regenerative and wellness interventions has created a powerful economic sector that, in some areas of nonsurgical spine care, is projected to surpass traditional medicine. Many of these therapies lack robust clinical evidence, yet the absence of data does not equate to inefficacy. These resulting strategic challenges will likely have a greater effect on spine surgeons who aredependent primarily on insurance-based reimbursement. At the same time, integrating validated regenerative options can broaden the surgical practice portfolio and better match patient preferences for personalized, minimally invasive care. Policy changes expanding coverage for evidence-based regenerative treatments may further accelerate this shift.

CONCLUSIONS: To remain relevant in an increasingly patient-driven health care environment, spine surgeons and organizations such as the International Society for the Advancement of Spine Surgery must proactively adapt to the growth of regenerative and wellness medicine. Failure to engage may relegate spine surgery largely to trauma, tumor, and infection, while regenerative and wellness strategies could dominate the management of painful degenerative spine disorders.

CLINICAL RELEVANCE: Regenerative and wellness medicine is rapidly reshaping how patients with degenerative spine conditions seek care, forcing spine surgeons to decide whether to integrate these modalities or risk losing a growing segment of nonsurgical spine patients.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

41412801

Language

English

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