Document Type
Article
Publication Date
7-1-2025
Abstract
Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a mitochondrial fusion protein, in their homeostasis. OPA1 knockdown in NP cells altered mitochondrial size and cristae shape and increased the oxygen consumption rate. OPA1 governed the morphology of multiple organelles, including peroxisomes, early endosomes and cis-Golgi and loss resulted in the dysregulation of autophagy. Metabolic profiling and
Recommended Citation
Madhu, Vedavathi; Hernandaz-Meadows, Miriam; Coleman, Ashley; Sao, Kimheak; Inguito, Kameron; Haslam, Owen; Boneski, Paige; Sesaki, Hiromi; Barve, Ruteja; Collins, John; and Risbud, Makarand, "The Loss of OPA1 Accelerates Intervertebral Disc Degeneration and Osteoarthritis in Aged Mice" (2025). Department of Orthopaedic Surgery Faculty Papers. Paper 245.
https://jdc.jefferson.edu/orthofp/245
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
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PubMed ID
40595596
Language
English
Included in
Cellular and Molecular Physiology Commons, Enzymes and Coenzymes Commons, Orthopedics Commons, Surgery Commons
Comments
This article is the author’s final published version in Nature Communications, Volume 16, Issue 1, 2025, Article number 5996.
The published version is available at https://doi.org/10.1038/s41467-025-60933-9. Copyright © The Author(s) 2025.