Document Type


Publication Date

November 2006


This article has been peer reviewed. It is the author's final version prior to publication in the Journal of Minimally Invasive Gynecology, 13(6):539-545, November 2006. The published version is available at under the title "GnRH analogs: Options for endometriosis-associated pain treatment"; copyright is retained by Elsevier, Inc.


Basic science research into the mechanism of the development of endometriosis, its persistence and resulting pain has begun to improve our understanding of how various therapeutic options work. While none of the available treatments resolves the underlying disease process, there are a growing number of alternatives. One of the more recent classes of medical options includes the GnRH agonist and antagonists. While at present this class of medical options is the most expensive and involved in implementation, they prove invaluable in terms of offering an aggressive, successful alternative for many patients. Furthermore, they may act directly on endometrial lesions in a therapeutic manner. This discussion will be oriented toward endometriosis pain management, but many of the medical manipulations may be therapeutic for infertility treatment as well if only by preventing the need for aggressive or emergency surgical management of endometriosis, especially in young women.