Document Type
Article
Publication Date
10-20-2024
Abstract
OBJECTIVE: A recent clinical trial demonstrated that the use of apixaban was safe and equal to enoxaparin (LMWH) in post-operative gynecologic oncology patients. This study aimed to determine if these findings are applicable in a diverse patient population at a single site urban academic medical center.
METHODS: This was a retrospective cohort study of patients who underwent an exploratory laparotomy for confirmed or presumed gynecologic cancer from the years 2017-2023 at a single-site urban academic medical center. Venous thromboembolism (VTE) prophylaxis with LMWH was standard practice at our institution up until January 2021 after which apixaban became standard for post-operative prophylaxis in our division. Baseline demographic and clinical characteristics of patients receiving apixaban post-operatively were compared to the population previously receiving enoxaparin. The primary outcome was a VTE event within 90 days of surgery. Secondary outcomes included major and minor bleeding events.
RESULTS: Two hundred fifteen patients met inclusion criteria, of which 65 were discharged on enoxaparin and 150 were discharged on apixaban. Baseline characteristics in terms of age, race/ethnicity and BMI found no significant difference between the two groups. Rates of any VTE event within 90 days of surgery were similar for apixaban and LMWH (3.33 % vs. 4.61 %, p = 0.6). Secondary outcomes demonstrated that the rate of a major bleeding event in apixaban group was 1.31 % and LMWH group was 3.08 %, (p = 0.38). Minor bleeding events in the apixaban group were comparable to the LMWH group (10.60 % vs 10.16 %, p = 0.5).
CONCLUSIONS: In this real world, urban setting, for women undergoing laparotomy for gynecologic cancer, apixaban as post-operative VTE prophylaxis showed no increase in VTE events and appeared safe with no increase in bleeding events compared to LMWH. This study adds to the literature demonstrating that apixaban is safe and effective for VTE prophylaxis in our gynecologic oncology patients.
Recommended Citation
Diamond, Victoria; Gerber, Katherine; Merli, Geno J.; Mercier, Rebecca J.; Shafer, Aaron; and Rosenblum, Norman G., "Apixaban Versus Enoxaparin to Prevent Venous Thromboembolism in Post-operative Patients With Gynecologic Cancers at an Urban Academic Medical Center" (2024). Department of Obstetrics and Gynecology Faculty Papers. Paper 116.
https://jdc.jefferson.edu/obgynfp/116
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
39498419
Language
English
Included in
Chemicals and Drugs Commons, Health Services Research Commons, Obstetrics and Gynecology Commons
Comments
This article is the author's final published version in Gynecologic Oncology Reports, Volume 56, 2024, Article number 101535.
The published version is available at https://doi.org/10.1016/j.gore.2024.101535.
Copyright © 2024 The Author(s)