Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study-A Nonrandomized Clinical Trial on Large and Giant Aneurysms

Authors

• Ajay K. Wakhloo
• Paul Jenkins
• Philip M. Meyers
• Alexander L. Coon
• Peter T. Kan
• Ajit S. Puri
• Joost de Vries
• Giuseppe Lanzino
• Mark D. Bain
• Koji C. Ebersole
• Babu G. Welch
• Aclan Dogan
• Pascal Jabbour, Thomas Jefferson UniversityFollow
• J. Mocco
• Adnan H. Siddiqui
• Aquilla S. Turk
• Philipp Taussky
• Ricardo A. Hanel

Document Type

Article

Publication Date

4-17-2026

Comments

This article is the author’s final published version in Neurosurgery Practice, Volume 7, Issue 2, 2026, Article number e000222.

The published version is available at https://doi.org/10.1227/neuprac.0000000000000222. Copyright © The Author(s) 2026.

Abstract

BACKGROUND AND OBJECTIVES: The prospective single-arm nonrandomized SCENT (Surpass Intracranial Aneurysm Embolization System Pivotal) trial on flow diverter treatment of large and giant intracranial aneurysms (IA) was analyzed for patients' age and IA characteristics affecting stroke and occlusion rates over 5 years (Trial registration NCT01716117).

METHODS: Impact on major ipsilateral stroke and IA occlusion was studied by stratifying age as 65 years and younger vs older than 65. Kaplan-Meier estimates of time to both endpoints, stratified by age, were created. Univariate predictors of time-to-stroke were analyzed using univariable proportional hazards regression models. Limited bivariable modeling was also attempted.

RESULTS: Of 180 patients with large or giant IA enrolled, 119 were 65 years and younger, whereas 61 were older than 65 years. The 3-year risk of stroke for the older than 65 years group (19.7%) was more than double that of the 65 years and younger group (9.2%),

CONCLUSION: Age older than 65 was associated with an increased risk of stroke and predictive of incomplete healing and increased time to healing.

Recommended Citation

Wakhloo, Ajay K.; Jenkins, Paul; Meyers, Philip M.; Coon, Alexander L.; Kan, Peter T.; Puri, Ajit S.; de Vries, Joost; Lanzino, Giuseppe; Bain, Mark D.; Ebersole, Koji C.; Welch, Babu G.; Dogan, Aclan; Jabbour, Pascal; Mocco, J.; Siddiqui, Adnan H.; Turk, Aquilla S.; Taussky, Philipp; and Hanel, Ricardo A., "Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study-A Nonrandomized Clinical Trial on Large and Giant Aneurysms" (2026). Department of Neurosurgery Faculty Papers. Paper 302.
https://jdc.jefferson.edu/neurosurgeryfp/302

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

42007246

Language

English