Document Type
Article
Publication Date
1-14-2026
Abstract
Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).
Recommended Citation
Gharabaghi, Alireza; Groppa, Sergiu; Casas, Elena; Schnitzler, Alfons; Muñoz-Delgado, Laura; Marshall, Vicky L.; Karl, Jessica; Zhang, Lin; Alvarez, Ramiro; Feldman, Mary S.; Soileau, Michael J.; Luo, Lan; Walter, Benjamin L.; Wu, Chengyuan; Lei, Hong; Herz, Damian M.; Nanduri, Devyani; Salazar, Claudia A.; Luca, Corneliu; and Weiss, Daniel, "Real-World Multicenter Assessment of Sustained Clinical Outcomes After Digital Deep Brain Stimulation" (2026). Department of Neurosurgery Faculty Papers. Paper 297.
https://jdc.jefferson.edu/neurosurgeryfp/297
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
41535352
Language
English
Comments
This article is the author's final published version in NPJ Digital Medicine, Volume 9, Issue 1, 2026, Article Number 133.
The published version is available at https://doi.org/10.1038/s41746-025-02315-5. Copyright © The Authors.