Document Type
Article
Publication Date
1-1-2025
Abstract
OBJECTIVE: Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to identify pre-operative resting-state functional MRI (rs-fMRI) patterns associated with seizure freedom following LITT in mesial TLE.
METHODS: We analyzed rs-fMRI data from 28 patients with mesial TLE who underwent LITT, classifying them into seizure-free (SF) and not seizure-free (NSF) groups based on 12-month post-operative outcomes. Independent component analysis (ICA) was used to identify subject-specific brain networks, and generalized linear models (GLM) were employed to assess associations between pre-operative spatial patterns of ICA-derived functional connectivity (FC) and surgical outcomes, controlling for clinical variables.
RESULTS: Significant differences in brain ICA-derived FC patterns were observed between SF and NSF groups, with SF exhibiting more locally distributed ICA-derived FC patterns around the mesial temporal lobe, including the posterior orbitofrontal cortex (OFC) and anterior parahippocampal gyrus (PHG). In contrast, NSF demonstrated more diffusely distributed ICA-derived FC patterns encompassing the insula and thalami.
SIGNIFICANCE: These findings highlight the potential of pre-operative rs-fMRI as a prognostic tool for identifying TLE patients more likely to benefit from LITT. Further validation in larger cohorts is warranted to confirm these results and optimize patient selection for surgical interventions.
Recommended Citation
Alizadeh, Mahdi; Miao, J.; Matias, Caio; Hines, Kevin J.; Skidmore, Christopher T T.; Sperling, Michael R.; Tracy, Joseph I; Sharan, Ashwini; and Wu, Chengyuan, "Independent Component Analysis of Resting-State Fmri Identifies Regions Associated With Seizure Freedom After Laser Interstitial Thermal Therapy for Temporal Lobe Epilepsy" (2025). Department of Neurosurgery Faculty Papers. Paper 281.
https://jdc.jefferson.edu/neurosurgeryfp/281
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
41376770
Language
English
Comments
This article is the author's final published version Frontiers in Neurology, Volume 16, January 2025, Article Number 1675066.
The published version is available at https://doi.org/10.3389/fneur.2025.1675066. Copyright © 2025 Alizadeh, Miao, Matias, Hines, Skidmore, Sperling, Tracy, Sharan and Wu.