Document Type
Article
Publication Date
6-20-2023
Abstract
Stroke remains a major burden on patients, families, and healthcare professionals, despite major advances in prevention, acute treatment, and rehabilitation. Preclinical basic research can help to better define mechanisms contributing to stroke pathology, and identify therapeutic interventions that can decrease ischemic injury and improve outcomes. Animal models play an essential role in this process, and mouse models are particularly well-suited due to their genetic accessibility and relatively low cost. Here, we review the focal cerebral ischemia models with an emphasis on the middle cerebral artery occlusion technique, a "gold standard" in surgical ischemic stroke models. Also, we highlight several histologic, genetic, and in vivo imaging approaches, including mouse stroke MRI techniques, that have the potential to enhance the rigor of preclinical stroke evaluation. Together, these efforts will pave the way for clinical interventions that can mitigate the negative impact of this devastating disease.
Recommended Citation
Sokolowski, Jennifer D; Soldozy, Sauson; Sharifi, Khadijeh A; Norat, Pedro; Kearns, Kathryn N; Liu, Lei; Williams, Ashley M; Yağmurlu, Kaan; Mastorakos, Panagiotis; Miller, G Wilson; Kalani, M Yashar S; Park, Min S; Kellogg, Ryan T; and Tvrdik, Petr, "Preclinical Models of Middle Cerebral Artery Occlusion: New Imaging Approaches to a Classic Technique" (2023). Department of Neurosurgery Faculty Papers. Paper 210.
https://jdc.jefferson.edu/neurosurgeryfp/210
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
37409019
Language
English
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Neurology, Volume 14, 2023, Article number 1170675.
The published version is available at https://doi.org/10.3389/fneur.2023.1170675.
Copyright © 2023 Sokolowski, Soldozy, Sharifi, Norat, Kearns, Liu, Williams, Yağmurlu, Mastorakos, Miller, Kalani, Park, Kellogg and Tvrdik.
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