Document Type
Article
Publication Date
8-19-2025
Abstract
INTRODUCTION: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.
METHODS: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).
RESULTS: The GM-CSF expression patterns varied by cell type and organ, with CD4
DISCUSSION: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and the correlation between its expression and the overall phenotype of effector memory CD4
Recommended Citation
Azizi, Gholamreza; Rasouli, Javad; Naziri, Hamed; Gonzalez, Michael V.; Garifallou, James; Zhang, Guang-Xian; Ciric, Bogoljub; and Rostami, Abdolmohamad M., "GM-CSF Production by Immune Cells in Steady State and Autoimmune Neuroinflammation Mapped Using Fate Reporting Mice" (2025). Department of Neurology Faculty Papers. Paper 374.
https://jdc.jefferson.edu/neurologyfp/374
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
40904462
Language
English
Comments
This article is the author's final published version in Frontiers in Immunology, Volume 16, August 2025, Article Number 1617074.
The published version is available at https://doi.org/10.3389/fimmu.2025.1617074. Copyright © Azizi, Rasouli, Naziri, Gonzalez, Garifallou, Zhang, Ciric and Rostami. First published in Frontiers In Immunology.