Document Type
Article
Publication Date
2-27-2024
Abstract
BACKGROUND: Comparative evaluations of preventive migraine treatments can help inform clinical decision making for managing migraine in clinical practice.
METHODS: An anchored matching-adjusted indirect comparison analysis was conducted using pooled participant-level data from two phase 3 atogepant trials (ADVANCE and PROGRESS) and one phase 2/3 rimegepant trial (BHV3000-305) to evaluate the relative efficacy and safety/tolerability of atogepant and rimegepant as preventive migraine treatments. Participants receiving atogepant 60 mg once daily, rimegepant orally disintegrating tablet 75 mg once every other day, and placebo were included. Only participants meeting the BHV3000-305 inclusion/exclusion criteria were analyzed: ≥6 monthly migraine days and ≤18 monthly headache days at baseline. The primary efficacy assessment of interest was change in monthly migraine days across weeks 1-12.
RESULTS: There were 252 participants in the atogepant group and 348 in the rimegepant group. Across weeks 1–12, atogepant 60 mg demonstrated a significantly greater reduction in mean monthly migraine days compared with rimegepant 75 mg (mean difference [95% CI]: −1.65 [−2.49, −0.81]; p < 0.001). Both atogepant and rimegepant demonstrated similar safety/tolerability profiles.
CONCLUSION: In this matching-adjusted indirect comparison analysis, oral atogepant 60 mg once daily demonstrated a significantly greater reduction in monthly migraine days compared with rimegepant 75 mg orally disintegrating tablet once every other day.
Recommended Citation
Tassorelli, Cristina; Onishchenko, Kateryna; Halker Singh, Rashmi B.; Duan, Molly; Dupont-Benjamin, Laure; Hemstock, Matthew; Voller, Corey; McAllister, Peter; Nahas, Stephanie J.; Gandhi, Pranav; and Ailani, Jessica, "Comparative Efficacy, Quality of Life, Safety, and Tolerability of Atogepant and Rimegepant in Migraine Prevention: A Matching-Adjusted Indirect Comparison Analysis" (2024). Department of Neurology Faculty Papers. Paper 337.
https://jdc.jefferson.edu/neurologyfp/337
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Supplemental Tables
PubMed ID
38410850
Language
English
Comments
This article is the author's final published version in Cephalalgia, Volume 44, Issue 2, Feb 2024.
The published version is available at https://doi.org/10.1177/03331024241235156. Copyright © International Headache Society 2024.