BACKGROUND: Selective IgA deficiency (SIgAD) is the most prevalent inborn errors of immunity with almost unknown etiology. This study aimed to investigate the clinical diagnostic and prognostic values of lymphocyte subsets and function in symptomatic SIgAD patients.
METHODS: A total of 30 available SIgAD patients from the Iranian registry and 30 age-sex-matched healthy controls were included in the present study. We analyzed B and T cell peripheral subsets and T cell proliferation assay by flow cytometry in SIgAD patients with mild and severe clinical phenotypes.
RESULTS: Our results indicated a significant increase in naïve and transitional B cells and a strong decrease in marginal zone-like and switched memory B-cells in SIgAD patients. We found that naïve and central memory CD4
CONCLUSION: SIgAD patients have varied cellular and humoral deficiencies. Therefore, T cell and B cell assessment might help in better understanding the heterogeneous pathogenesis and prognosis estimation of the disease.
Bagheri, Yasser; Moeini Shad, Tannaz; Namazi, Shideh; Tofighi Zavareh, Farzaneh; Azizi, Gholamreza; Salami, Fereshteh; Sadani, Somayeh; Hosseini, Ali; Saeidi, Mohsen; Pashangzadeh, Salar; Delavari, Samaneh; Mirminachi, Babak; Rezaei, Nima; Abolhassani, Hassan; Aghamohammadi, Asghar; and Yazdani, Reza, "B Cells and T Cells Abnormalities in Patients With Selective IgA Deficiency" (2023). Department of Neurology Faculty Papers. Paper 314.
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