SignificanceMultiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune diseases characterized by accumulation of myeloid cells in the central nervous system (CNS). Both harmful and beneficial myeloid cells are present in EAE/MS, and a goal of MS therapy is to preferentially remove harmful myeloid cells. The receptor for CSF-1 (CSF-1R) is found on myeloid cells and is important for their survival. CSF-1R can bind two ligands, CSF-1 and IL-34, but it is not known whether their functions in EAE/MS differ. We found that blocking CSF-1 depleted only harmful myeloid cells in the CNS and suppressed EAE, whereas blocking IL-34 had no effect. Thus, we propose that blocking CSF-1 could be a therapy for MS.
Hwang, Daniel; Seyedsadr, Maryam S; Ishikawa, Larissa; Boehm, Alexandra; Sahin, Ziver; Casella, Giacomo; Jang, Soohwa; Gonzalez, Michael V; Garifallou, James P; Hakonarson, Hakon; Zhang, Weifeng; Xiao, Dan; Rostami, A M; Zhang, Guang-Xian; and Ciric, Bogoljub, "CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation" (2022). Department of Neurology Faculty Papers. Paper 283.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.