LGI1 encephalitis with squamous lung-cell carcinoma: Resolution after tumor resection.

Authors

Akash Virupakshaiah, Thomas Jefferson University
Marinos Dalakas, Thomas Jefferson University; University of Athens Medical SchoolFollow
Neeja Desai, Thomas Jefferson University
Scott Mintzer, Thomas Jefferson UniversityFollow
Jeffrey Ratliff, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

10-9-2020

Comments

This article is the author’s final published version in Neurology(R) Neuroimmunology & Neuroinflammation, Volume 8, Issue 1, October 2020, Article number e905.

The published version is available at https://doi.org/10.1212/NXI.0000000000000905. Copyright © Virupakshaiah et al.

Abstract

Encephalitis with leucine-rich glioma-inactivated-1 (LGI1) immunoglobulin G (IgG) anti-bodies classically presents with cognitive impairment and characteristic faciobrachial dystonicseizures.1In a murine model, human LGI1 IgG caused reduction of Kv1.1 channels andα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor receptors resulting in neuro-nal hyperexcitability indicating probable pathogenicity of LGI1 antibodies.2LGI1 autoimmu-nity is associated with malignancy in less than 10% of cases, including small cell lung cancer,prostate and colon cancer, squamous cell skin carcinoma, and neuroendocrine pancreaticcancer.3,4We present a case of LGI1 encephalitis only partially responsive to immunotherapywith eventual complete resolution after resection of a squamous cell lung carcinoma.

Recommended Citation

Virupakshaiah, Akash; Dalakas, Marinos; Desai, Neeja; Mintzer, Scott; and Ratliff, Jeffrey, "LGI1 encephalitis with squamous lung-cell carcinoma: Resolution after tumor resection." (2020). Department of Neurology Faculty Papers. Paper 232.
https://jdc.jefferson.edu/neurologyfp/232

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

33037051

Language

English