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This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission

This article has been peer reviewed. It is the author’s final published version in Frontiers in Neurology

Volume 8, Issue DEC, December 2017, Article number 687.

The published version is available at DOI: 10.3389/fneur.2017.00687. Copyright © Kudlacek et al.


Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it is well documented that pathological HFOs are suppressed by antiepileptic drugs (AEDs), the effect of AEDs on normal HFOs is not well known. In this experimental study, we have explored whether physiological HFOs (sharp-wave ripples) of hippocampal origin respond to AED treatment. The results show that application of a single dose of levetiracetam or lacosamide does not reduce the rate of sharp-wave ripples. In addition, it seems that these new generation drugs do not negatively affect the cellular and network mechanisms involved in sharp-wave ripple generation, which may provide a plausible explanation for the absence of significant negative effects on cognitive functions of these drugs, particularly on memory. © 2017 Kudlacek, Chvojka, Posusta, Kovacova, Hong, Weiss, Volna, Marusic, Otahal and Jiruska.

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