Document Type
Article
Publication Date
12-1-2017
Abstract
The idea that synchronous neural activity underlies cognition has driven an extensive body of research in human and animal neuroscience. Yet, insufficient data on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-brain setting. Through the lens of memory encoding and retrieval processes, we construct whole-brain connectivity maps of fast gamma (30-100 Hz) and slow theta (3-8 Hz) spectral neural activity, based on data from 294 neurosurgical patients fitted with indwelling electrodes. Here we report that gamma networks desynchronize and theta networks synchronize during encoding and retrieval. Furthermore, for nearly all brain regions we studied, gamma power rises as that region desynchronizes with gamma activity elsewhere in the brain, establishing gamma as a largely asynchronous phenomenon. The abundant phenomenon of theta synchrony is positively correlated with a brain region's gamma power, suggesting a predominant low-frequency mechanism for inter-regional communication.
Recommended Citation
Solomon, E. A.; Kragel, J. E.; Sperling, Michael R.; Sharan, Ashwini; Worrell, G.; Kucewicz, M.; Inman, C. S.; Lega, B.; Davis, K. A.; Stein, J. M.; Jobst, B. C.; Zaghloul, K. A.; Sheth, S. A.; Rizzuto, D. S.; and Kahana, M. J., "Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition." (2017). Department of Neurology Faculty Papers. Paper 140.
https://jdc.jefferson.edu/neurologyfp/140
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
29167419
Comments
This article has been peer reviewed. It is the author’s final published version in Nature Communications
Volume 8, Issue 1, December 2017, Article number 1704
The published version is available at DOI: 10.1038/s41467-017-01763-2. Copyright © Solomon et al.