Assessing the Utility of Patient-Reported Outcome Measures (PROMs) in Schizophrenic Patients with Impaired Self-Perception

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Publication Date

4-3-2025

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Presentation: 19:15

Abstract

It is estimated that 1 in 300 people have schizophrenia representing approximately 24 million people worldwide. Research in patients with established psychosis has produced conflicting results providing evidence that a core set of PROM assessments is needed. The purpose of this capstone was to identify relevant PROMs currently used in schizophrenia and assess their effectiveness and utility in schizophrenic patients with impaired self-perception. A scoping review using PubMed® literature search from 2010 to the present was conducted using keywords schizophrenia and patient-reported outcome measures. Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines were used to evaluate the psychometric properties of identified PROMs about their reliability and validity. Three PROMs were identified as schizophrenic-specific Quality of Life (QoL) measures validated in English speaking schizophrenic patients using: the Schizophrenia Quality of Life Scale (SQLS), the Satisfaction with Life Domains Scale (for Schizophrenia) (SLDS), and the Schizophrenia Quality of Life Questionnaire (SQoL). Only (SQoL) had all three psychometric properties evaluated with published findings demonstrating adequate reliability, validity and sensitivity to change. Both the SQLS and SLDS were found to be reliable, but both lacked published results for sensitivity to change and only the SQLS had results establishing validity. The results of this review highlight the limited availability of reliable, validated English language schizophrenia-specific PROMs evaluating QoL, thereby affecting the utility of these tools to adequately evaluate the schizophrenic patient perspective. To bridge this gap, both new and revised PROMs are necessary in order to more effectively enable providers and researchers to evaluate these important aspects of the schizophrenic patient experience.

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English

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