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The COVID-19 pandemic has disproportionately affected Black and Latino communities in terms of morbidity, mortality, and vaccination hesitancy. This review of the literature utilized a systematic approach to identify facilitators of COVID-19 vaccine hesitancy among Black and Latino individuals in the United States. 18 papers from PubMed and other sources were identified and screened. Upon completion, 11 papers were included in the review. 6 major themes were identified: historical influences, the development and approval process, safety, access to information and resources, efficacy, and other factors. Other factors included fear of deportation, politics, and conspiracy theories. These findings indicate that better access to credible information, especially in Spanish, is needed to reduce most vaccine concerns among Black and Latino communities. Additionally, understanding the historical influences facilitating vaccine hesitancy and listening to community voices is necessary to increase trust in the healthcare system. Overall, more research must be conducted to examine racial and ethnic disparities in COVID-19 vaccine hesitancy to decrease morbidity and mortality disparities associated with the COVID-19 pandemic.