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The number of deaths by opioid overdose have quadrupled since 1999. In 2019 alone, there were about 50,000 deaths caused by overdoses and the numbers increase each year. While there are harm reduction techniques used to fight against this epidemic, they are clearly not sufficient as the number of deaths have been rising at staggering rates. A safe injection site is a facility that is staffed with medically trained individuals to operate a safe environment for those using injection drugs like opioids. In this systematic review of the literature is focused on obtaining the perceptions of the public specifically on safe injection sites. Two research databases, PubMed and Scopus, were utilized for this review. Peer-reviewed articles were screened based on specific eligibility criteria. Five peer-reviewed papers were selected for data extraction out of 261 screened articles. There were many similarities found amongst the papers but also differences. Two of the five studies found that more than half of participants were in favor of SIS. Political party affiliation was found to be the most likely correlating factor for support of SIS in four of the five papers. The differences amongst the results may be attributed to the vastly different countries including the US, France, and Canada. Data showing support for SIS in the US may be the start to potentially increasing their use against the opioid crisis in the US.