CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation

Authors

Gabriela L. Cosma, Thomas Jefferson UniversityFollow
Laurence Eisenlohr, University of Pennsylvania; Children's Hospital of Philadelphia Research Institute

Document Type

Article

Publication Date

4-27-2018

Comments

This article has been peer reviewed. It is the author’s final published version in F1000Research, Volume 7, April 2018, Article number 508.

The published version is available at https://doi.org/10.12688/f1000research.14115.1. Copyright © Cosma & Eisenlohr

Abstract

Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines. Thus far, CD8 T-cell vaccination strategies have had limited success therapeutically in contrast to those targeting antibody-based immunity. However, if the current challenges and gaps in the understanding of T-cell biology are overcome, the full potential of rational CD8 T-cell vaccine design might be realized. Here, we review recent progress in this direction, focusing on target selection and maintenance of function in the settings of chronic infections and cancers.

Recommended Citation

Cosma, Gabriela L. and Eisenlohr, Laurence, "CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation" (2018). Department of Microbiology and Immunology Faculty Papers. Paper 93.
https://jdc.jefferson.edu/mifp/93

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

29770202

Language

English