Immunogenicity and Safety of a Rabies-Based Highly Pathogenic Influenza a Virus H5 Vaccine in Cattle
Document Type
Article
Publication Date
8-19-2025
Abstract
The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.
Recommended Citation
Paran, Nir; Wirblich, Christoph; Olal, Catherine; Tarquinio, Alessandro; Lohmeyer, Kimberly H.; Kurup, Drishya; Schultz-Cherry, Stacey; Shittu, Ismaila; Gray, Gregory C.; Bente, Dennis A.; Olafson, Pia U.; and Schnell, Matthias J., "Immunogenicity and Safety of a Rabies-Based Highly Pathogenic Influenza a Virus H5 Vaccine in Cattle" (2025). Department of Microbiology and Immunology Faculty Papers. Paper 196.
https://jdc.jefferson.edu/mifp/196
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
40830096
Language
English
Comments
This article is the author's final published version in npj Vaccines, Volume 10, Issue 1, August 2025, Article Number 197.
The published version is available at https://www.doi.org/10.1038/s41541-025-01238-2.Copyright © The Author(s) 2025.