Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.

Authors

Sandra Bonne-Annee, Thomas Jefferson UniversityFollow
Jessica A. Hess, Thomas Jefferson UniversityFollow
David Abraham, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

11-2011

Comments

This article is the authors' final version prior to publication in Immunologic Research, Volume 51, November 2011, Pages 205-14.

The final publication is available at Springer via https://doi.org/10.1007/s12026-011-8258-2. Copyright © Springer

Abstract

Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in the mechanisms used by the immune response to kill the parasite and that a vaccine with a single antigen may be suitable as a prophylactic vaccine to prevent human strongyloidiasis.

Recommended Citation

Bonne-Annee, Sandra; Hess, Jessica A.; and Abraham, David, "Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model." (2011). Department of Microbiology and Immunology Faculty Papers. Paper 149.
https://jdc.jefferson.edu/mifp/149

PubMed ID

22101674

Language

English