Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fevers in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans.
Vuyyuru, Raja; Liu, Hongqi; Manser, Tim; and Alugupalli, Kishore, "The characteristics of Borrelia hermsii infection in human hematopoeitic stem cell-engrafted mice mirror those of human relapsing fever" (2011). Department of Microbiology and Immunology Faculty Papers. Paper 14.