Document Type
Article
Publication Date
3-5-2018
Abstract
BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved.
METHODS: The level of cytosolic Ca
RESULTS: Here, we demonstrated that TNFα induced extracellular Ca
CONCLUSIONS: Our study provides the evidence supporting a novel mechanism by which TNFα induces extracellular Ca
Recommended Citation
Zhu, Jianjun; Jin, Mingpeng; Wang, Jiaojiao; Zhang, Hui; Wu, Yousheng; Li, Deyang; Ji, Xiaoying; Yang, Hushan; Yin, Chun; Ren, Tingting; and Xing, Jinliang, "TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells" (2018). Department of Medical Oncology Faculty Papers. Paper 76.
https://jdc.jefferson.edu/medoncfp/76
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
29506556
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Journal of Experimental and Clinical Cancer Research, Volume 37, Issue 1, March 2018, Article number 43.
The published version is available at https://doi.org/10.1186/s13046-018-0714-6 . Copyright © Zhu et al.